APP and epilepsy: In the PTC, θ–low-γ PAC in particular is likely to reflect inhibitory network interactions predominantly occurring in the HC, as previously demonstrated in a transgenic epilepsy mouse model with impaired GABAergic inhibition.47 Consistent with this, APP/PS1 mice showed reduced θ–low-γ PAC compared to WT mice across the entire observation window (Fig. 4D, ii; all comparisons with P  < 0.01 or P  < 0.001), whereas no genotype differences were observed in θ–high-γ PAC (data not shown).