APP and early-onset autosomal dominant Alzheimer disease: To provide better insight in the underlying E/I imbalances contributing to the observed fE/I changes in APP/PS1 mice, the analysis was expanded to θ–γ PAC, a metric strongly relying on hippocampal–cortical inhibitory network activity34 that is impaired in Alzheimer's disease patients38 and mouse models.39,41 Hence, we computed θ–γ PAC from the LFP signals recorded from the HC of APP/PS1 mice over the period between 3 and 11 months of age and compared the results to those of WT mice of the same age.