A literature review conducted on January 20, 2025, using PubMed, Google Scholar, and Web of Science with the keywords “POC1B,” “cone dystrophy,” “cone-rod dystrophy,” “optic disc swelling,” and “papilledema” revealed no previous reports of POC1B-associated COD or CORD presenting with bilateral optic disc swelling. The gene discussed is POC1B; the disease is optic papillitis.