Additionally, KL-6, interleukin (IL)-15, serum chitinase-3-like-1 protein (YKL-40), IL-6, interferon-α, and CD4+CXCR4+ T cells have also been reported as prognostic biomarkers in anti-MDA5+ DM patients, although none have been widely accepted so far (26–29). This evidence concerns the gene CHI3L1 and dermatomyositis.