We observed that the high-risk group is significantly enriched in several signaling pathways related to tumor invasiveness and metastasis, including epithelial-mesenchymal transition (EMT), hypoxia, TNFA-NF-κB signaling, inflammatory response, angiogenesis, KRAS, apoptosis, mitosis, and IL2/STAT5 signaling (37–45). Here, TNF is linked to neoplasm.