The expression level of UPF1 was evaluated by qRT–PCR in 22 snap-frozen NPC tissues and 14 noncancerous nasopharyngeal tissues derived from Sun Yat-Sen University Cancer Center, and the results revealed that UPF1 expression was significantly downregulated in tumor tissues compared with that in nontumor controls (Figure 1A). Here, UPF1 is linked to neoplasm.