The expression level of UPF1 was evaluated by qRT–PCR in 22 snap-frozen NPC tissues and 14 noncancerous nasopharyngeal tissues derived from Sun Yat-Sen University Cancer Center, and the results revealed that UPF1 expression was significantly downregulated in tumor tissues compared with that in nontumor controls (Figure 1A). The gene discussed is UPF1; the disease is nasopharyngeal carcinoma.