Conversely, increased IFN-γ is known to enhance antigen presentation and apoptotic susceptibility in malignant progenitors (39), supporting a paradigm in which iron removal promotes not only detoxification but also immunologic rejuvenation of hematopoiesis, which ultimately translates into a reduction in the progression of these patients to AML. The gene discussed is IFNG; the disease is acute myeloid leukemia.