Specifically, HDHD5, PNPLA4, MAPK1, ATG7, and ACAT2 were significantly upregulated, whereas ABHD4, ABHD8, GK5, CPT2, YJEFN3, CRYAB, HSPA1A, and HDAC3 were notably downregulated in tumor tissues compared to normal samples (Figure 1F). The gene discussed is HSPA1A; the disease is neoplasm.