Specifically, HDHD5, PNPLA4, MAPK1, ATG7, and ACAT2 were significantly upregulated, whereas ABHD4, ABHD8, GK5, CPT2, YJEFN3, CRYAB, HSPA1A, and HDAC3 were notably downregulated in tumor tissues compared to normal samples (Figure 1F). This evidence concerns the gene HDHD5 and neoplasm.