Specifically, HDHD5, PNPLA4, MAPK1, ATG7, and ACAT2 were significantly upregulated, whereas ABHD4, ABHD8, GK5, CPT2, YJEFN3, CRYAB, HSPA1A, and HDAC3 were notably downregulated in tumor tissues compared to normal samples (Figure 1F). Here, HDAC3 is linked to neoplasm.