CRYAB and neoplasm: Specifically, HDHD5, PNPLA4, MAPK1, ATG7, and ACAT2 were significantly upregulated, whereas ABHD4, ABHD8, GK5, CPT2, YJEFN3, CRYAB, HSPA1A, and HDAC3 were notably downregulated in tumor tissues compared to normal samples (Figure 1F).