HCC cells commonly exhibit an imbalance in the expression of the methionine adenosyltransferase (MAT) family, characterized by downregulation of the tumor-suppressive MAT1A and upregulation of the oncogenic MAT2A, resulting in abnormalities in the S-adenosylmethionine (SAM) synthesis pathway (238, 239). This evidence concerns the gene MAT1A and hepatocellular carcinoma.