Fructose-1,6-bisphosphatase 1 (FBP1) is a key tumor-suppressing enzyme that is inactivated through multi-layered regulation: 1) Epigenetic Silencing: Histone deacetylase-mediated loss of H3K27ac modification suppresses FBP1 promoter activity (ChIP-seq confirmed enrichment of HDAC1/2 at the FBP1 promoter region) (74); and 2) Ubiquitination-Dependent Degradation: The E3 ubiquitin ligase TRIM28 directly binds FBP1, promoting its 26S proteasome-dependent degradation (validated by co-immunoprecipitation assays) (75). This evidence concerns the gene FBP1 and neoplasm.