TLR3/4 activation results in the upregulation of chemokines CCL2/MCP-1 and immunosuppressive factors VEGFA and MMP2, which collectively promotes lung cancer invasion and metastasis through the adaptor protein TICAM1/TRIF and the activation of downstream MAPK/NF-κB signaling pathway (215). The gene discussed is MMP2; the disease is lung cancer.