In addition, studies have found that IFN-γ released by immunotherapy-activated CD8+ T cells and radiotherapy-activated macrophages can independently and synergistically inhibit SLC7A11.This leads to a decrease in cystine uptake, which in turn increases lipid peroxidation and ferroptosis, making tumor cells sensitive to radiotherapy (263). This evidence concerns the gene SLC7A11 and neoplasm.