ESR1 and neoplasm: After biopsy of the left supraclavicular lymph node with follow up IHC, tumor was characterized as ER-negative, PR-negative, Her-2 (0:90%;1+: 8%; 2+: 2%; total grade: 1+), AR-negative, mutant P53-positive (80%), Ki-67-positive, (90%), TROP-2 (3+), PD-L1 (CPS≈30, clone SP263).