- two variants of IL37 gene (rs3811046 and rs3811047) may be associated with susceptibility to COVID-19 (TG genotype of SNP rs3811046 showed a significantly increased frequency in patients compared to controls (61.0 VS. 38.0%; OR = 2.55; 95% CI = 1.45-4.50; p = 0.002). GA genotype of SNP rs3811047 also showed an increased frequency in patients compared to controls (39.0 VS. 24.0%; OR = 2.02; 95% CI = 1.10-3.71; p = 0.033; pc = 0.165). The gene discussed is IL37; the disease is COVID-19.