In this study CHIP-associated mutations in hematopoietic stem cells of several genes, including those encoding the enzymes DNA methyltransferase 3 alpha (DNMT3A) and tet methylcytosine dioxygenase 2 (TET2), were found to be associated with protection from AD (Bouzid et al., 2023). This evidence concerns the gene DNMT3A and Alzheimer disease.