RBFOX1 and Alzheimer disease: For RBFOX1, a key splicing factor implicated in synaptic function that may play a role in cognitive resilience to AD, lifestyle exposures such as physical activity and diet have been linked to changes in expression (Gehman et al., 2011; Vuong et al., 2018; Ahn et al., 2024; Black et al., 2017; Raghavan et al., 2020).