In the presence of AD pathology with increasingly dysfunctional systems over the course of the disease, the action of cognitive resilience transcription factors like MEF2C, RBFOX1, ZCCHC17, and CREB may help neurons maintain healthy and plastic synaptic connections and avoid hyperexcitability (Barker et al., 2021; Vuong et al., 2018; Bartosch et al., 2024; Kida, 2012). This evidence concerns the gene MEF2C and Alzheimer disease.