SCN1A and Alzheimer disease: Moreover, the expression of RNA binding fox-1 homolog 1 (RBFOX1) has been reported to have an inverse relationship with cognitive decline in the human early AD brain; RBFOX1 modulates the alternative splicing of ion channels [including sodium voltage-gated channel alpha subunit 1 (SCN1A), calcium channel, voltage-dependent, L type, alpha 1C subunit (CACNA1C)], GABA receptor subunits, and genes involved in synaptic vesicle docking (Gehman et al., 2011; Vuong et al., 2018; Raghavan et al., 2020).