ZCCHC17 and Alzheimer disease: Another critical factor to maintain synapses and thus cognitive resilience from AD is the transcriptional regulator Zinc Finger CCHC-type containing 17 (ZCCHC17), which upregulates genes involved in synaptic function and whose expression is negatively correlated with tau tangle burden and positively correlated with resilience (Bartosch et al., 2024).