Furthermore, polymorphisms such as IL-1β −511 C/T, IL-6 −174 G/C, IL-10 −1082 G/A, IFN-γ +874 A/T, and TNF-α −308 G/A show a strong correlation with an increased risk of GDM in the Han women from northern China (specifically, Hebei Province). The gene discussed is TNF; the disease is gestational diabetes.