The prognostic value of HBP, IL-6, PCT, CRP, Lac and SOFA scores in patients with severe pneumonia complicated with sepsis (Table 5; Figure 4): ROC curve analysis showed that IL-6 had the greatest area under the receiver operating characteristic curve, which was 0.80 (95% confidence interval 0.71 - 0.87), HBP was 0.73 (95% confidence interval 0.66 - 0.81), and SOFA score was 0.78 (95% confidence interval 0.72 - 0.85). The gene discussed is IL6; the disease is Sepsis.