Logistic regression analysis disclosed that HBP ( OR = 1.006, 95% CI:1.002 ~ 1.011, P < 0.05), IL-6 ( OR = 1.004, 95% CI:1.001 ~ 1.007, P < 0.05 ) and SOFA ( OR = 1.026, 95% CI: 1.145 ~ 1.484, P < 0.05 ) scores were independent risk factors affecting sepsis (all P < 0.05), for every one-unit increase in HBP, IL-6 levels, and SOFA score, the risk of 28-day mortality in patients increases by 0.6%, 0.4%, and 2.6%, respectively. The gene discussed is IL6; the disease is Sepsis.