Pre-hot patients exhibited increased inflammatory (CXCR4, BCL2, FYN, NLRC5, LTB, CCL3, IKBKE, IRF7, JAK3, TNFAIP3, CXCL9) and cancer progression gene markers (i.e., CXCR4, BCL2, FYN) (Lin et al., 2014; Hosseini-Khah et al., 2021; Huang et al., 2022) (Figures 4A, C–E; Supplementary Figures S2, S3A–F, S4A–D; Supplementary Tables S7-S9). Here, JAK3 is linked to cancer.