In animal studies, a high-fat diet was used to evaluate the effect of Pg on liver fibrosis, and Pg-LPS injected into the gingiva near the first molars of rats fed a high-fat diet caused inflammation of the rats' livers, and the degree of inflammation was more significant than in the group not treated with Pg-LPS (Fujita et al. 2018). The gene discussed is JUP; the disease is Hepatic fibrosis.