Holten’s research demonstrated that insulin action in skeletal muscles, both in individuals with type 2 diabetes and healthy controls, was enhanced after 6 weeks of RT, primarily due to increased content of glucose transporter-4 (GLUT4) and enhanced expression or activity of various insulin proteins (Tayebi et al., 2019; Holten et al., 2004). This evidence concerns the gene INS and type 2 diabetes mellitus.