CLEC7A and Alzheimer disease: Fentanyl-treated AD mice showed significantly greater Clec7a+ coverage at plaques compared to saline controls in both cortex (Figure 3C; AD-Sal = 35.79±2.80, AD-ROU = 63.75±1.97, p = 2.39E-5) and hippocampus (AD-Sal = 15.59±1.48, AD-ROU = 56.13±1.38, p = 3.8E-7).