MAPT and Alzheimer disease: MIC or control diet begun at 4 months for the 3xTg AD (CTRL n = 15, MIC n = 15) and nonTg control (CTRL n = 15, MIC = 15) groups to determine the drug’s ability to suppress the age-dependent accumulation Aβ ant tau pathology as well as microglia reactivity (Fig. 1a).