3xTg AD mice are a widely used model of AD that develop age-dependent pathology, originally generated by Oddo et al. through co-injection of Presenilin 1 Methionine-146-Valine (PS1M146V) and Amyloid Precurser Protein Swedish (APPSwe) transgenes, which are linked to familial Alzheimers Disease (fAD), as well as the tauP30IL transgene, which is linked to frontotemporal dementia (FTD) [45, 46]. Here, PSEN1 is linked to familial Alzheimer disease.