IL4 and rheumatoid arthritis: In contrast, the 2,311 ligand-receptor DEG-associated canonical pathways were related to activating immune responses, including pathways involving macrophages, fibroblasts, and endothelial cells in rheumatoid arthritis, wound healing signaling, interleukin-4 and −13, and preeclampsia (Fig. 4D and Supplementary material table 3).