Mouse keratinocytes which express Aldh3a2, Aldh3b1 and Aldh3b2, had no significant growth defect when only one or two of Aldh3 genes were knocked out (Aldh3a2 single knockout or Aldh3b1/Aldh3b2 double knockout) in the setting of FA deficiency. Here, ALDH3B2 is linked to autoimmune lymphoproliferative syndrome.