Aberrant cytoplasmic mislocalization and aggregation of FUS, hnRNPA1, and hnRNPA2 are pathological hallmarks in the brains of patients afflicted with neurodegenerative diseases such as amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD)5, 20, 23, 24. This evidence concerns the gene HNRNPA1 and amyotrophic lateral sclerosis.