RNA-seq data have showed that the overexpression of γ-H2AX in 19 types of cancers and γ-H2AX was positively correlated with the poor survival rate of hepatocellular carcinoma (HCC) patients, indicating the pivotal role of γ-H2AX in HCC (Hu et al., 2023). This evidence concerns the gene H2AX and hepatocellular carcinoma.