In the unadjusted model (without covariates adjusted), Model I (adjusted for sex and age) and Model II (adjusted for age, gender, season, education level, PIR, BMI, smoking status, drinking alcohol status, depression, sleep, asthma, hay fever, and IgE), continuous serum vitamin E concentrations showed no association with eczema risk. This evidence concerns the gene IGHE and depressive symptom measurement.