ICAM5 and Mental deterioration: Cognitive decline (ADAS-Cog11) was primarily driven by immune-related processes, such as classical and alternative complement activation and humoral immune responses, with the involvement of several proteins including CX3CL1, PEA15, ICAM5, SERPINA3, and PPIA, while CDR-SB was enriched for metabolic and structural pathways, including glycolysis, ketone metabolism, cytoskeletal organization, and regulation of apoptosis.