Overall, 52 proteins, including ACHE, ADGRB2, CBLN4, EPHA5, FABP3, GDI1, NEFL, NPTXR, PEA15, SCN3B, UCHL1, YWHAE, YWHAG, and YWHAZ were commonly altered across both comparisons, showing significant changes already in MCI (due-to-AD) participants and further deviation from control levels in the AD Dementia group (Fig. 3B–C, E). Here, ADGRB2 is linked to dementia.