LRRK2 and Parkinson disease: In PD models, IFN-γ exacerbates neuronal susceptibility by enhancing the pathological leucine-rich repeat kinase 2 (LRRK2)-G2019S pathway, thereby impairing Akt signaling and nuclear factor of activated T-cells (NFAT) activation in both neurons and microglia (Panagiotakopoulou et al., 2020).