Several studies have shown that TREM2 facilitates microglial engulfment of synaptic components (Fracassi et al., 2022; McQuade et al., 2020; Filipello et al., 2018), with the R47H mutation promoting excessive synaptosome phagocytosis, which may result in abnormal synaptic elimination and accelerated AD progression (Popescu et al., 2022; Das et al., 2023; Penney et al., 2023; Gratuze et al., 2020). The gene discussed is TREM2; the disease is Alzheimer disease.