On the contrary, suppression of stiffness‐sensor molecule (integrin β1 or Piezo1) significantly downregulated Ki67 (Figure 2E), PCNA and CCND1 expressions (Figure 2F; Figure S2) in cells on high‐stiffness substrate, also reversely testifying the contribution of high stiffness stimulation on cell proliferation in HCC. The gene discussed is CCND1; the disease is hepatocellular carcinoma.