Another study shows that UBC9‐induced‐PFKFB3 SUMOylation competitively prevents PFKFB3 polyubiquitination to promote aerobic glycolysis and proliferation of glioblastoma cells,54 also highlighting the role of protein posttranslational modification in modulating PFKFB3 expression and glycolysis. Here, UBE2I is linked to glioblastoma.