P53 (R273H, R175H, R248Q or R249S)‐EphA‐2‐CAR‐DC can suppress the growth of tumours expressing the correlated TP53 mutant in animal models. In addition, the combination of the immune checkpoint inhibitors could further reverse immunosuppressive TME and globally activate T‐cell responses. This evidence concerns the gene EPHA2 and neoplasm.