P53 (R273H, R175H, R248Q or R249S)‐EphA‐2‐CAR‐DC can suppress the growth of tumours expressing the correlated TP53 mutant in animal models. In addition, the combination of the immune checkpoint inhibitors could further reverse immunosuppressive TME and globally activate T‐cell responses. The gene discussed is TP53; the disease is neoplasm.