Third, we explicitly couple immune phenotypes with tumour evolutionary trajectories, revealing that C4 tumours represent immune‐inflamed “hot” states (PD‐L1/IFNγ upregulated, MES‐like), whereas C2 tumours represent immune‐desert “cold” states (low MHC, CD160 upregulated, PN‐like proliferative). Here, CD274 is linked to neoplasm.