M2 macrophages also contribute to the control of lipolysis and deficiency in tribbles pseudokinase 1 (Trib1), a protein that is essential for M2 macrophage differentiation, is associated with increased lipolysis and hypertriglyceridaemia in mice on a high‐fat diet (Satoh et al., 2013). The gene discussed is TRIB1; the disease is hypertriglyceridemia.