Also the OTX2 locus was not detected as significant aberration by GISTIC in both non-miRNA-altered subtypes, but similar to PB-miRNA tumor focal OTX2 and whole chromosome 14 gains (including OTX2) were present in PB-MYC/FOXR2 (n = 4) and PB-RB1 cases (n = 2; Fig. 3d and e and Supplementary Fig. 6a). This evidence concerns the gene RB1 and neoplasm.