Changes of HSPB1 (heat shock protein beta 1) in AD brains have been reported [53, 55] and alteration of Hspa1a (Heat Shock Protein Family A (Hsp70) Member 1A) was observed in the 3 × Tg mice with NF-α1/CPE treatment (Fig. S1). This evidence concerns the gene HSPB1 and Alzheimer disease.