GRIA1 and Alzheimer disease: For example, glutamate ionotropic receptor AMPA type subunit 2 (GRIA2) has been found decreased in AD patients [53], and Gria1 was also altered in the 3 × Tg mice with NF-α1/CPE treatment (Fig. S1), suggesting the role of AMPA subunits in the pathogenesis of AD.