Additionally, increased P2RX7 gene expression was detected in DCLK1 and reactive DPP10 astrocytes and in damage-associated TPT1 microglia in the hippocampus of AD patients (n = 26) compared with NCs (n = 22) (SFig. 1) (data source [43], details in the supplementary files). Here, P2RX7 is linked to Alzheimer disease.