AKT1 and cancer: Notably, genes were enriched in “bladder cancer, proteoglycans in cancer, pathways in cancer, and PI3K-Akt signaling pathway.” Additional enrichment was seen in “immune-related and metabolic pathways such as AGE-RAGE signalling in diabetic complications, Th17 cell differentiation, and fluid shear stress and atherosclerosis,” pointing to a diverse involvement in oncogenic and inflammatory signalling cascades (Fig. 8E).