AKT1 and cholangiocarcinoma: Consistently, Histopathological analysis confirmed significant lipid deposition in malignant tissues relative to adjacent normal controls; a phenotype was recapitulated in vivo using two orthotopic CCA murine models (YAP/AKT vs. saline controls; KRAS/p19 vs. saline controls) (Fig. 1D-F, Supplementary Fig. 1A-B).