Furthermore, adipocytes possess endocrine functions, and the relationship between obesity and central precocious puberty (CPP) in girls involves metabolic hormones and neuropeptides, in particular the adipokine leptin and the neuropeptide kisspeptin, which both interact with and modulate the hypothalamic circuits regulating reproductive functions [57]. This evidence concerns the gene LEP and obesity due to melanocortin 4 receptor deficiency.