Moreover, previous studies had shown that B7H3 can upregulate IL-2, IL-6, IL-17, and TGF-β1 levels while diminishing IFN-γ production [39], and B7H3 antibodies can promote the infiltration of CD8+ T cells in the tumor microenvironment [17, 18]. The gene discussed is TGFB1; the disease is neoplasm.