Even though most SARS-CoV-2 proteins have proven to be immunogenic we decided to focus on the Spike and Nucleocapsid proteins as main targets of immune responses to viral infection using the reference sequences of the Wuhan-Hu-1 isolate (ref. seq accession number Genebank: 1798174254; Fig. 1d and zoom in Additional File 1: Fig S1f and g). This evidence concerns the gene CHMP5 and viral infectious disease.