In the OVA-expressing B16F10 (B16F10-OVA) tumor model, CFSE-labeled OT-I-positive CD8+ T cells were adoptively transferred into B16F10-OVA tumor inoculated mice, and 72 h later increased proliferation of OT-I cells in the tumor-draining lymph nodes (TdLNs) was observed in the SUP3-treated group compared to the control group (Fig. 3K). Here, CD8A is linked to neoplasm.