RhoA expression has been reported to correlate positively with the IFN signature in lupus patients and to directly promote STAT1 phosphorylation downstream of IFNAR [56].Whether RhoA prenylation and function are enhanced in FHBL2-derived monocytes and thereby contribute to the amplification of IFN signaling in these subjects remains to be determined. Here, STAT1 is linked to systemic lupus erythematosus.