For example, the findings from Huang’s report indicated that the 53-aa length conserved peptide chain encoded by lncRNA HOXB-AS3 in CRC, when bound to heterogeneous nuclear ribonucleoprotein A1 (hnRNPA1), antagonizes its mediated PKM splicing regulation, enables the formation of low-activity pyruvate kinase PKM2 isoform (Fig. 2), inhibits glucose metabolism reprogramming [62]. The gene discussed is PKM; the disease is colorectal carcinoma.