Dysregulated AIM2 function has implications beyond infection control; recent oncological studies reveal that decreased AIM2 expression in colorectal and breast tumors correlates with increased inflammatory cytokine milieu and poor prognosis [38], whereas in glioblastoma, AIM2 expression is markedly elevated and plays a role in impairing mitochondrial function [39]. Here, AIM2 is linked to breast neoplasm.