Upregulation of guanine nucleotide-binding protein-4 (GNB4) in glioma cells increases cancer progression, while silencing GNB4 restrains tumor growth by promoting the expression of pyroptotic proteins and inflammatory factors via cyclic GMP–AMP Synthase – Stimulator of Interferon Genes (cGAS-STING) pathway [224]. This evidence concerns the gene STING1 and neoplasm.