Moreover, lobaplatin as a third-generation of platinum-based anti-neoplastic agent, induces GSDME-dependent pyroptosis in nasopharyngeal carcinoma (NPC) through caspase-3 activation and modulation of cellular Inhibitor of Apoptosis Protein 1/2 (cIAP1/2) proteasomal degradation [373]. The gene discussed is CASP3; the disease is nasopharyngeal carcinoma.