In terms of splicing isoforms and their effect on breast cancer cells’ behavior, Hergueta-Redondo et al. showed that among four identified GSDMB isoforms, GSDMB-1 and GSDMB-2 isoforms promote invasion and motility in MCF-7 cell line, whereas the suppression of these isoforms in the HCC1954 cell line decrease the invasive and migratory phenotype. The gene discussed is GSDMB; the disease is breast carcinoma.