CD8A and melanoma: Beyond its well-established role in infection-driven inflammation, NLRP3 has profound cancer relevance: recent studies have shown that NLRP3 activation in tumor-associated macrophages can amplify immunosuppressive myeloid cell infiltration in pancreatic cancer [33], while in other contexts, such as melanoma, NLRP3-dependent IL-1β release enhances CD8+ T-cell recruitment to the tumor bed [34].