Another study by Liu et al. showed that CAR T cells trigger tumor cell pyroptosis through granzyme B–mediated activation of caspase-3 and cleavage of gasdermin E (GSDME), which then activates caspase-1–dependent GSDMD in macrophages, causing cytokine release syndrome (CRS). The gene discussed is CASP1; the disease is congenital rubella syndrome.