CASP3 and central nervous system cancer: In regard to glioma, several small molecules and drugs, such as galangin (through caspase-3/GSDME axis) [381], benzimidazole (through NF-kB/NLRP3/GSDMD axis) [382], kaempferol (through GSDME and ROS) [383], and AT7519 (through caspase-3 cleavage of GSDME) [384] have shown the capability of inducing pyroptosis.