To examine this possibility, we collected a confirmed list of immunosuppressive genes and found a positive correlation between p62 and the main suppressors of T-cell immune function on the tumor cell surface, including EBAG9, PVR, B7-H3, TNFRSF14, TGFB1, and PD-L1, in most cancers (Fig. 6A). This evidence concerns the gene SQSTM1 and cancer.