Consistent with this, our pan-cancer analysis revealed that in 14 tumor types—BRCA, CESC, COAD, ESCA, HNSC, KIRC, LIHC, LUAD, LUSC, PAAD, PCPG, PRAD, READ, THCA—high p62 expression was associated with increased tumor purity and decreased infiltration immune cells, specifically, of CD8+ T cells, CD4+ T cells, and dendritic cells. Here, CD4 is linked to cancer.