KCNQ1 and type 2 diabetes mellitus: The Indigenous community from which the IS1 and IS2 cell lines were derived is known to have common variation in the KCNQ1 gene, a well-established locus for type 2 diabetes, where more than half of the community carries KCNQ1 risk alleles that affect beta cell mass and have a notable impact on type 2 diabetes risk [22, 30, 31].