ADHFE1, CNRIP1, FNB1, IKZF1, LIFR, PPP2R5C, SDC2, SEPT9, SHOX2, SNCA and ZNF132 are only partially methylated in low-grade adenomas and can be used to differentiate low-grade adenomas from high-grade adenomas or adenocarcinomas. This evidence concerns the gene ADHFE1 and adenocarcinoma.