The positions of these 15 CRs on chromosomes are presented in Fig. 2C. Among the 15 DE-CRs, the expression levels of IFIT3, SP140, GADD45B, MOV10, SMARCD3, JAK2, GADD45G, TDRD7, PCGF5, LMNB1, SAP30, and DTX3L were upregulated in the TB cohort, whereas those of SETD6, RSAD1, and TLE2 were downregulated (Fig. 2D). The gene discussed is GADD45B; the disease is tuberculosis.