NFKB1 and neoplasm: It may be noteworthy to point out that chelerythrine and sanguinarine, which were shown to inhibit PLCε as potently as ZPT and Zn2+ in this study, have been used in folk medicine72 for their wide range of biological effects including not only anti-inflammatory activity mediated by downregulation of NF-κB and proinflammatory cytokine expression but also anti-tumour activity72–74, hinting that PLCε inhibition might form a molecular basis for their action.