For example, TAMs and TANs are recruited to the tumour stroma by the action of chemokines secreted from cancer cells, such as CXCL1, CXCL2, CXCL8 and CCL2, and become a secondary source of chemokines which affect tumour proliferation, angiogenesis and metastasis, such as CXCL1, CXCL2, CXCL8 and CCL264,65. This evidence concerns the gene CCL2 and neoplasm.