CCND1 and hepatocellular carcinoma: To determine whether hepatocytes in states of plasticity are intrinsically resistant to proliferation and therefore less likely to contribute to tumorigenesis, we employed three oncogenes— myristoylated-Akt1 (AKT*), KrasG12D, and Ccnd1—each known to induce hepatocyte proliferation and HCC development within 7–10 months35–38.