For example, several AMLs from the TP53, NPM1, and AML-MR subtypes contained mainly cells resembling mature monocytes, whereas other cases of the same subtype contained mainly cells resembling immature or a mixture of immature and mature cells (Fig. 2a, Supplementary Figs. 6–8), suggesting the presence of significant biological differences beyond current genomic classification schemes. Here, NR3C2 is linked to acute myeloid leukemia.